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KMID : 0376219840210010101
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Chonnam Medical Journal
1984 Volume.21 No. 1 p.101 ~ p.113
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The fine structure of the giant cell tumor
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崔在權/Choi, Jae Kwon
尹在龍/金伯潤/安圭胤/李垠周/Yoon, Jae Rhyong/Kim, Baik Yoon/An, Kyu Youn/Lee, Eun Joo
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Abstract
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A case of giant cell tumor developed at the proximal end of the ulna was removed surgically at the Chonnam University Hospital, and was observed with electron microscope and the following results were obtained.
l. Giant cells were characterized by having many mitochondria, abundant granular endoplasmic reticulum, significant amount of vacuolar structures, and poorly developed Golgi apparatus. Apposed membranes with 200A interval resembling to the intercellular space of the epithelia were noted in the peripheral cytoplasm of a giant cell. Cell surfaces were mostly wavy and had many irregular microvilli.
2. Stromal cells were divided roughly into two main types by their shapes, one was round cells, and the other spindle cells.
i) Round stromal cells were characterized by having round or oval nuclei and clear cytoplasm with poorly developed cell organelles. These cells were thought to be immature mesenchymal cells.
ii) Spindle shaped stromal cells were elongated cells and contained various cytoplasmic components of diverse patterns, and thus could be subdivided into two or more cell types. The first type of cells contained abundant granular endoplasmic reticulum and many free polyribosomes, the second type of cells had moderate amount of scattered and fragmented granular endoplasmic reticulum, dense granules, and fewer free ribosomes, and the the third type of cells had moderatly abundant granular endoplasmic reticulum with dilated cisternae often containing amorphous contents. These different patterns of granular endoplasmic reticulum and some other cytoplasmic components might reflect the differences in degrees of maturation of single cell type or the differences in the direction of differentiation. Although no fusions among the giant cells or stromal cells were found, similarity in fine structures of giant cells and spindle shaped stromal cells, and presence of apparent cell membranes with intercellular space within the giant cells suggested that giant cells were formed by the fusion of stromal cells possibly by misdirected maturation of immature mesenchymal cells.
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